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                                                                                                                                                                                                                                                    4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        	                                                                               
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                                                                    	                             1      
                           $                                   
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  	   	    ' 4 / 	 $ 2 	  , ! ( … U        c   w,  xº  xì  y4  }œ  ƒ>  Šð�	¤4&òòï ¿ V¤µx�5G¼	p
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  &<?xml version="1.0"?><Features nextValidID="16"><Feature recentID="0" name="6xHis" directionality="1" translationMW="840.86" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="6986" maxFusedRunOn="6986" detectionMode="exactProteinMatch"><Segment range="6966-6983" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;6xHis affinity tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="HHHHHH"/></Q></Feature><Feature recentID="1" name="thrombin site" directionality="1" translationMW="627.76" type="CDS" allowSegmentOverlaps="0" cleavageArrows="5117" consecutiveTranslationNumbering="1" maxRunOn="6959" maxFusedRunOn="6959" detectionMode="exactProteinMatch"><Segment range="5106-5123" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;thrombin recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="LVPRGS"/></Q></Feature><Feature recentID="2" name="6xHis" directionality="1" translationMW="840.86" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="6959" maxFusedRunOn="6959" detectionMode="exactProteinMatch"><Segment range="5079-5096" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;6xHis affinity tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="HHHHHH"/></Q></Feature><Feature recentID="3" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4988-5006" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="RBS" type="RBS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5046-5068" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;efficient ribosome binding site from bacteriophage T7 gene 10 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/2676996&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/2676996&quot;&gt;Olins and Rangwala, 1989&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5007-5031" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="S-Tag" directionality="1" translationMW="1748.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="6959" maxFusedRunOn="6959" detectionMode="exactProteinMatch"><Segment range="5130-5174" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;affinity and epitope tag derived from pancreatic ribonuclease A&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="KETAAAKFERQHMDS"/></Q></Feature><Feature recentID="7" name="T7 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7050-7097" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="lacI promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4598-4675" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="bom" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2271-2413" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;basis of mobility region from pBR322&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="rop" directionality="2" translateFirstCodonAsMet="1" translationMW="7196.20" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2515-2706" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;rop&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Rop protein, which maintains plasmids at low copy number&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="VTKQEKTALNMARFIRSQTLTLLEKLNELDADEQADICESLHDHADELYRSCLARFGDDGENL*"/></Q></Feature><Feature recentID="11" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="12-467" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1497-2085" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="KanR" directionality="2" translationMW="30979.95" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="560-1375" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-Ia&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to kanamycin in bacteria or G418 (GeneticinÂ®) in eukaryotes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSHIQRETSCSRPRLNSNMDADLYGYKWARDNVGQSGATIYRLYGKPDAPELFLKHGKGSVANDVTDEMVRLNWLTEFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF*"/></Q></Feature><Feature recentID="14" name="lacI" directionality="2" translateFirstCodonAsMet="1" translationMW="38559.52" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3515-4597" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli. &lt;/i&gt;This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="VKPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNRVAQQLAGKQSLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVERSGVEACKAAVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMALGAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSVDRLLQLSQGQAVKGNQLLPVSLVKRKTTLAPNTQTASPRALADSLMQLARQVSRLESGQ*"/></Q></Feature><Feature recentID="15" name="PPP2R1A" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="5190-6959" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA*"/></Q></Feature></Features>
  |<?xml version="1.0"?><Primers nextValidID="5"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="R1" sequence="tcagtggtggtggtggtggtgctcgagtcaggcgagagacagaacagtcagagcc" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" visible="0"><BindingSite location="6931-6985" boundStrand="1" annealedBases="tcagtggtggtggtggtggtgctcgagtcaggcgagagacagaacagtcagagcc" meltingTemperature="77"><Component hybridizedRange="6931-6985" bases="tcagtggtggtggtggtggtgctcgagtcaggcgagagacagaacagtcagagcc"/></BindingSite><BindingSite simplified="1" location="6931-6985" boundStrand="1" annealedBases="tcagtggtggtggtggtggtgctcgagtcaggcgagagacagaacagtcagagcc" meltingTemperature="77"><Component hybridizedRange="6931-6985" bases="tcagtggtggtggtggtggtgctcgagtcaggcgagagacagaacagtcagagcc"/></BindingSite></Primer><Primer recentID="1" name="F1" sequence="agcacatggacagcccagatctgggtaccatggcggcggccg" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" visible="0"><BindingSite location="5160-5201" boundStrand="0" annealedBases="agcacatggacagcccagatctgggtaccatggcggcggccg" meltingTemperature="78"><Component hybridizedRange="5160-5201" bases="agcacatggacagcccagatctgggtaccatggcggcggccg"/></BindingSite><BindingSite simplified="1" location="5160-5201" boundStrand="0" annealedBases="agcacatggacagcccagatctgggtaccatggcggcggccg" meltingTemperature="78"><Component hybridizedRange="5160-5201" bases="agcacatggacagcccagatctgggtaccatggcggcggccg"/></BindingSite></Primer><Primer recentID="2" name="T7-ter" sequence="TGCTAGTTATTGCTCAGCGG" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" visible="0"><BindingSite location="7035-7054" boundStrand="1" annealedBases="TGCTAGTTATTGCTCAGCGG" meltingTemperature="58"><Component hybridizedRange="7035-7054" bases="TGCTAGTTATTGCTCAGCGG"/></BindingSite><BindingSite simplified="1" location="7035-7054" boundStrand="1" annealedBases="TGCTAGTTATTGCTCAGCGG" meltingTemperature="58"><Component hybridizedRange="7035-7054" bases="TGCTAGTTATTGCTCAGCGG"/></BindingSite></Primer><Primer recentID="3" name="T7" sequence="TAATACGACTCACTATAGGG" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" visible="0"><BindingSite location="4987-5006" boundStrand="0" annealedBases="TAATACGACTCACTATAGGG" meltingTemperature="49"><Component hybridizedRange="4987-5006" bases="TAATACGACTCACTATAGGG"/></BindingSite><BindingSite simplified="1" location="4987-5006" boundStrand="0" annealedBases="TAATACGACTCACTATAGGG" meltingTemperature="49"><Component hybridizedRange="4987-5006" bases="TAATACGACTCACTATAGGG"/></BindingSite></Primer><Primer recentID="4" name="Primer 1" sequence="cagggcctccagatcctc" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" visible="0"><BindingSite location="5900-5917" boundStrand="1" annealedBases="cagggcctccagatcctc" meltingTemperature="58"><Component hybridizedRange="5900-5917" bases="cagggcctccagatcctc"/></BindingSite><BindingSite simplified="1" location="5900-5917" boundStrand="1" annealedBases="cagggcctccagatcctc" meltingTemperature="58"><Component hybridizedRange="5900-5917" bases="cagggcctccagatcctc"/></BindingSite></Primer></Primers>
  £<Notes>
<UUID>c4c73727-5cc9-41b7-ac71-bf67db07f03f</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pT7-6Ã—His-PPP2R1A(human)</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2017.7.13</Created>
<LastModified UTC="20:27:8">2025.7.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d               E              ÿÿÿÿYô? P                                                                                                                                                             <StrandColors><TopStrand><ColorRange range="5186..5188" colors="green"/><ColorRange range="6956..6958" colors="light blue"/></TopStrand><BottomStrand><ColorRange range="5186..5188" colors="green"/><ColorRange range="6956..6958" colors="light blue"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
